New Delhi: The Country's top medical research body--India Council of Medical Research (ICMR) on Wednesday said that indiscriminate use of Convalescent Plasma Therapy (CPT) should be avoided as it does not reduce mortality in COVID-19 patients.
The apex medical research body issued Standard Operating Procedure (SoP) on plasma therapy and advised states to desist from its indiscriminate use.
"ICMR conducted an open-label phase II multicentre randomised controlled trial in India across 39 public and private hospitals on the use of convalescent plasma in the management of cases with moderate COVID-19 disease (PLACID Trial). It was concluded that CPT did not lead to a reduction in progression to severe COVID19 or all-cause mortality in the group that received CPT as compared to the group that did not receive CPT," said the ICMR in its new advisory.
"PLACID is the world's largest pragmatic trial on CPT conducted in 464 moderately ill laboratory-confirmed COVID-19 affected adults in real-world setting wherein no benefit of use of CPT could be established," it said.
The ICMR also mentioned that similar studies conducted in China and the Netherlands have also documented no significant benefit of CPT in improving the clinical outcomes of hospitalised COVID-19 patients, hence indiscriminate use of CPT is not advisable.
"It is speculated that convalescent plasma having a low concentration of specific antibody against SARS-CoV-2 may be less beneficial for treating COVID-19 patients as compared to plasma with a high concentration of such antibodies," said the guidance note.
"This ICMR advisory, therefore, embraces the principle that a potential donor for convalescent plasma should have sufficient concentration of antibody working against COVID19," it added.
