Hyderabad: Researchers at the University of Wisconsin have found aerobic exercise to increase brain functions that are normally impaired by Alzheimer’s disease in people that are at risk of developing the disease.
The results of this study are published in a special issue of Brain Plasticity devoted to Exercise and Cognition. Drugs currently available to treat AD have limited therapeutic capacity.
At a time when both the human and monetary costs of the disease are projected to rise dramatically in the coming decades, there is a critical need to provide individuals with readily-deployable strategies that can decrease the likelihood of acquiring the disease or slow its progression.
Researchers, therefore, investigated whether exercise training in asymptomatic individuals harbouring risk for AD improves markers associated with AD. This study is a significant step toward developing an exercise prescription that protects the brain against AD, even among people who were previously sedentary," explained lead investigator Ozioma C. Okonkwo, PhD, of the Wisconsin Alzheimer's Disease Research Center, University of Wisconsin School of Medicine and Public Health.
The study investigated 23 cognitively normal, relatively young older adults with a family history or genetic risk for AD. All patients had a sedentary lifestyle. They underwent a battery of assessments, including cardiorespiratory fitness testing, measurement of daily physical activity, brain glucose metabolism imaging (a measure of neuronal health), and cognitive function tests.
Half of the participants were randomly assigned to receive information about maintaining an active lifestyle but no further intervention. The other half participated in a moderate-intensity treadmill training program with a personal trainer, three times per week for 26 weeks.
Compared to the participants maintaining their usual level of physical activity, individuals assigned to the active training program improved their cardiorespiratory fitness, spent less time sedentary after the training program ended, and performed better on cognitive tests of executive functioning (but not episodic memory).
Executive function, an aspect of cognition that is known to decline with the progression of AD, comprises the mental processes enabling individuals to plan, focus attention, remember instructions, and juggle multiple tasks successfully.
This research shows that lifestyle behaviour - regular aerobic exercise - can potentially enhance brain and cognitive functions that are particularly sensitive to the disease. The findings are especially relevant to individuals who are at a higher risk due to family history or genetic predisposition.
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