Young Adults Show Serious Complications From Type 2 Diabetes

As per a study published in the New England Journal of Medicine, young adults show serious complications from Type-2 Diabetes.

South Texas youth whose Type 2 diabetes was followed for up to 15 years in the TODAY studies have made an immensely important contribution to understanding the early-onset form of the disease, clinicians and researchers at UT Health San Antonio and University Health’s Texas Diabetes Institute said today. The studies, published July 29 in the New England Journal of Medicine, showed that within 15 years of a Type 2 diabetes diagnosis, 60% of participants had at least one diabetes-related complication, and nearly a third of participants had two or more.

“Through this study, we really appreciated that Type 2 diabetes in youth is way more aggressive than the type of diabetes we see in their grandparents,” said Maria “Sukie” Rayas, MD, assistant professor of pediatric endocrinology at UT Health San Antonio. “Now we have affirmation of how bad the complications are and how rapidly they can actually occur,” said Elia Escaname, MD, assistant professor of pediatric endocrinology and medical director of the children’s clinic at the Texas Diabetes Institute.

The study conducted on West Side--Dr. Rayas and Dr. Escaname served as co-investigators of the San Antonio TODAY study, for which Jane Lynch, MD, professor of pediatric endocrinology, was the principal investigator. All patients attended appointments at University Health’s Texas Diabetes Institute on San Antonio’s West Side. TODAY stands for Treatment Options for Type 2 Diabetes in Adolescents and Youth. The study pointed out the lack of approved medications for children under 18 diagnosed with Type 2 diabetes. “We need to expand treatment options and explore medications that we use widely for adults with Type 2 diabetes to see if they are safe and effective for children,”Dr. Rayas said.

Beyond insulin, only metformin, liraglutide, and exenatide are approved by the U.S. Food and Drug Administration for the treatment of Type 2 diabetes in children and adolescents ages 10-17. Only insulin and metformin are approved for children under 10.

Health determinants--The TODAY findings also highlighted the study population’s lack of access both to healthy lifestyles and to medications and health care providers.

“Some families and children miss basic necessities such as healthy food options and parks and places where children can safely go out and play and exercise,” Dr. Escaname said. “We mustassess this when counseling lifestyle modifications. Lack of necessities is one of the main reasons children have developed an issue in the first place.”

Findings--Study participants were ages 10-17 at the time of enrollment, had been diagnosed with Type 2 diabetes within the past two years, and were overweight or had obesity. The average age of participants after the TODAY studies follow-up was 26.

TODAY found: 67% of participants had high blood pressure. Nearly 52% had dyslipidemia or high-fat levels in the blood. Nearly 55% had kidney disease. 32% had evidence of nerve disease. 51% had an eye disease. The TODAY studies’ diverse cohort is representative of U.S. youth diagnosed with type 2 diabetes. Study participants had regular, intensive diabetes management through the study at no cost during the original TODAY trial, which researchers note may have actually lowered the rate of complications.