According to the World Health Organisation, 39 million children under five years are overweight. Some 25% of Australian children and adolescents are overweight or obese. How parents contribute to their offspring's obesity risk is well established but the link between grandparents and grandchildren has been less clear. Our systematic review of studies involving more than 200,000 people around the world confirms obesity is transmitted across multiple generations of families. We still need to figure out why and how to break this cycle.
Setting up for a lifetime of health issues
Obesity among children and adolescents is associated with developing health problems. These include high blood pressure, cholesterol imbalance, insulin resistance, diabetes mellitus, accelerated growth and maturity, orthopaedic difficulties, psychosocial problems, increased risk of heart disease and premature mortality.
We examined the current global evidence on the association between grandparents who are overweight or obese and the healthy weight status of their grandchildren. We looked at 25 studies that involved 238,771 people from 17 countries. The combined data confirms obesity is transmitted multi-generationally not just from parent to child but also from grandparent to grandchild. We found children whose grandparents are obese or overweight are almost twice as likely to be obese or overweight compared to those whose grandparents are normal weight.
Nature and nurture?
Further research is needed into how children's obesity status is influenced by their grandparents but there are likely two pathways at work. The influence could be indirect via parents' genes or occur directly through the roles played by grandparents in children's upbringing.
Let's start with biological factors. Both egg and sperm cells contain molecules that respond to the nutritional intake of parents. This means traits that are susceptible to high weight gain can be passed on from grandparents to parents and then to their grandchildren. And evidence shows genetics, environmental factors, lifestyle and eating habits all play key roles in predisposing individuals to obesity.
What we eat and feed our family members can lead to the expression of certain genetic traits (a term referred to as epigenetics) which can then be transferred to successive generations. Due to shared familial, genetic, and environmental factors, obesity tends to aggregate within immediate families and studies have consistently reported an intergenerational transmission of obesity from parents to children.
Food intake can also influence health and biology across multiple generations. In Sweden, a study reported adequate food for paternal grandparents at ten years of age reduced heart disease and diabetes and increased longevity among their grandchildren.