Osaka [Japan]: Researchers have discovered that dipeptides containing 2-oxo-imidazole (2-oxo-IDPs) have extremely significant antioxidant activity. Also, they developed a technique to specifically and sensitively detect very minute concentrations of 2-oxo-IDPs and discovered for the first time that several forms of 2-oxo-IDPs are contained in meat, including beef, pork, and chicken.
Imidazole dipeptides (IDPs), which are abundant in meat and fish, are substances produced in the bodies of various animals, including humans, and have been reported to be effective in relieving fatigue and preventing dementia. However, the physiological mechanism by which IDPs exhibit these activities had not been determined previously.
A research team, led by Professor Hideshi Ihara from the Osaka Metropolitan University Graduate School of Science, was the first to discover 2-oxo-imidazole-containing dipeptides (2-oxo-IDPs) - which have one more oxygen atom than normal IDPs - and found that they are the most common variety of IDPs derivatives in the body. The researchers also found that they have remarkably high antioxidant activity.