Several studies have suggested a negative association of antibiotic use with vaccine-induced immunity in adults, but data are lacking in children, said researchers from the Rochester General Hospital Research Institute in the US. The findings published in the journal Pediatrics showed antibody measurements diphtheria-tetanus-cellular pertussis (DTaP), inactivated polio (IPV), Haemophilus influenzae type b (Hib), and pneumococcal conjugate (PCV) vaccines were lower in babies who took antibiotics compared to those who did not. These vaccines are aimed at controlling whooping cough, polio and other diseases.
"Antibiotic use in children below two years of age is associated with lower vaccine-induced antibody levels to several vaccines," said Michael E. Pichichero, from the Hospital's Center for Infectious Diseases and Immunology. In the study, the team observed 560 children aged between 6-24 months; of which 342 had antibiotic prescriptions while 218 did not.
The results showed that vaccine-induced antibody levels to several DTaP and PCV antigens were lower in children given antibiotics. A higher frequency of vaccine-induced antibodies below protective levels in children given antibiotics occurred at 9 and 12 months of age.
Further, antibiotic courses over time were negatively associated with vaccine-induced antibody levels. For each antibiotic course, the child received, pre-booster antibody levels to DTaP antigens were reduced by 5.8 per cent, Hib by 6.8 per cent, IPV by 11.3 per cent, and PCV by 10.4 per cent, and post booster antibody levels to DTaP antigens were reduced by 18.1 per cent, Hib by 21.3 per cent, IPV by 18.9 per cent, and PCV by 12.2 per cent. The drugs can disrupt gut bacteria, which appear to play a part in the body's response to vaccines, ScienceNews reported.