Madrid: The 13th round of La Liga action sees Barcelona travel to Celta Vigo after an important Champions League win, while Atletico Madrid visit Valencia after losing tamely to Liverpool and Real Madrid face Rayo Vallecano after being booed off by their own fans.
Here are some things to look out for this weekend in Spain:
1. Can erratic Celta upset Barca?
Sergi Barjuan leads Barcelona in Celta Vigo's Balaidos Stadium on Saturday for what will almost certainly be his last game in charge before Xavi Hernandez takes over.
Barca have improved slightly under Sergi, showing more aggression in their play, but the weaknesses that were so obvious under Ronald Koeman still remain, as does a long injury list that includes Sergio Aguero, Pedri, Ousmane Dembele, Sergino Dest, Sergi Roberto and Gerard Pique.
Celta have been erratic this season and their home form has been especially poor, but if players such as Nolito, Iago Aspas and Brais Mendez have a good day, they can still cause Barca a lot of problems on the break - and that appears to be one of Barca's weak points this season, reports Xinhua.
2. Real Madrid need to improve against Rayo
Two goals from Karim Benzema gave Real Madrid a much-needed Champions League win at home to Shakhtar Donetsk on Wednesday night, but Carlo Ancelotti's men were guilty of allowing Shakhtar to stay in the game and were booed off the pitch by some of their fans at the end of the game.
While that may say as much about the expectations of some supporters as it does about the team, Ancelotti needs to inject a bit more life into his side. Eduardo Camavinga could come into midfield, but with Gareth Bale back in training but not yet fully fit, Eden Hazard in apparent exile and Rodrygo injured, it looks as if most of the attacking focus will again fall on Benzema and Vinicius Jr.