Gold nanoparticles used for site-specific drug delivery improves cancer management, treatment: Study

A novel site-specific drug delivery method using gold nanoparticles can improve management and treatment of cancer, a recent global study by scientists suggests.

New Delhi: A novel site-specific drug delivery method using gold nanoparticles can improve management and treatment of cancer, according to a recent study carried out by a global group of scientists including Indians. Ministry of Science and Technology (DST), in a statement, said the study on 'gold nanoparticles' solutions will open new opportunities for better cancer management and treatment, and pave a way for future nanomedicine even beyond cancer.

There are more than 200 different types of cancers known which are currently being treated through surgery, chemotherapy, and radiation therapy. Many of these cancers can be cured if detected early and treated effectively. However, the available treatments are time-taking, expensive, and trigger numerous other side-effects and the actual health benefits of the therapy do not reach to the cancer patients effectively, the study said.

Researchers at Amity Centre for Nanobiotechnology and Nanomedicine (ACNN), have developed therapeutic agents with the help of nano-biotechnological approaches using a unique solution of ‘gold nanoparticles’ that helps in improving the site-specific drug delivery for cancer disease management and its effective treatment.

How does it work

'Gold nanoparticles' were formulated by the group - Hemant Kumar Daima, Akhela Umapathi and Prof. S.L. Kothari all from the ACCN. The solution will have a distinctive functional surface containing biomolecules and antibiotics for improved anticancer activity through selective generation of reactive oxygen species (ROS). The results have revealed that the appropriate surface corona on the gold nanoparticles was essential for effective cancer treatment in a selective manner, the Ministry said quoting the study.

The research was extended toward lung cancer cells using functional silver nanoparticles and selective anti-cancer effect originating from surface chemistry of silver nanoparticles was demonstrated in a paper. Both the studies have provided deeper understanding regarding the mechanism of anti-cancer actions of the functional nanoparticles. The research was a global effort with researchers from University of Miyazaki, Japan; and RMIT University, Australia actively participating in it. Now, the team is planning clinical studies on the formulated nanoparticles, it said.