New Delhi: Altering the levels of metabolites in the Kynurenine pathway, responsible for regulating eye colour, has been found to impact retinal health, according to a new study in flies. The study conducted by Max Planck Institute of Molecular Cell Biology and Genetics (MPI-CBG) in Germany investigated the classic Drosophila genes cinnabar, cardinal, white, and scarlet, named due to their role in eye colour pigmentation and in particular the formation of the brown pigment of the fly eye.
These genes encode components of the kynurenine pathway, a metabolic pathway responsible for regulating eye colour, among other various biological processes. Changes in this pathway can impact the health of the brain, including the retina. Metabolic pathways consist of a series of biochemical reactions in cells that convert a starting component into other products.
The scientists studied the role of these genes using flies as model, in whom this metabolic pathway is conserved. They used genetics, dietary changes, and biochemical analysis of metabolites to study different mutations of the fruit fly, Drosophila melanogaster. The researchers developed a biochemical analysis method, which allowed them to link levels of different metabolites of the pathway to retinal health.