Fremantle: The Artania cruise ship left the Australian port of Fremantle on Saturday, more than three weeks after it arrived, carrying dozens of sick passengers and crew.
Local media reported that some of the remaining passengers on board waved as the ship was leaving just after 1 pm (0500 GMT).
The German liner was carrying 79 of Western Australia's 541 coronavirus cases, according to local media.
Three people from the ship died from COVID-19 after it had docked, including a 42-year-old Philippine male crew member who passed away on Friday.
For most people, the new coronavirus causes mild or moderate symptoms, such as fever and cough that clear up in two to three weeks.
Read more:Cruise ship docks in Fremantle after denied entry in Asia